PF02218 - Repeat in HS1/Cortactin

Protein family information

B3RT04

B3RT04 Interpro sequence information

Triedas a dimer and trimer, did not work, unstructure

Sequence:

>tr|B3RT04|B3RT04_TRIAD Src substrate cortactin OS=Trichoplax adhaerens OX=10228 GN=TRIADDRAFT_21918 PE=4 SV=1
MWRAGVDTKFSTTESPEDDDWETDPDFVNDVTEEEQRFGSKTVEGSGSQRVLDMNKLRDD
VKDSDKKSKEGKLFHVTPKYSYGYGGQFGVQKDRMDKSAVSNSYQYVPEKHSSQTDFKQG
FGGKFGIQKDRQDKSAVGYDYSEKTALHSSQKDYSKGFGGKFGVQNDRQDKSAVGFDYTE
KTALHSSQKDYSKGFGGKFGVEKDKQDKSAVGFDYAEKNALHSSQKDYSKGFGGAFGVEK
DKQDKSAESWSYVGKSELHQSQKDYSKGFGGKFGVETEKQDKSAENWSYVGKNELHESQK
DYSRGFGGKFGVESDRQDKVW

MRF results:

Region 1: 80-301, 37 aa length, 6 units, TRUST 1.0
YSYGYGGQFGVQKDRMDKSAVSNSYQYVPEKHSSQTD
FKQGFGGKFGIQKDRQDKSAVGYDYSEKTALHSSQKD
YSKGFGGKFGVQNDRQDKSAVGFDYTEKTALHSSQKD
YSKGFGGKFGVEKDKQDKSAVGFDYAEKNALHSSQKD
YSKGFGGAFGVEKDKQDKSAESWSYVGKSELHQSQKD
YSKGFGGKFGVETEKQDKSAENWSYVGKNELHESQKD

TAPAS results:

tr_B3RT04_OX=10228_GN=TRIADDRAFT_21918_PE=4_SV=1,structured domain,CATH,90,161,1.20.1710.10/FF/31
tr_B3RT04_OX=10228_GN=TRIADDRAFT_21918_PE=4_SV=1,disordered region,IUPred,5,70
tr_B3RT04_OX=10228_GN=TRIADDRAFT_21918_PE=4_SV=1,disordered region,IUPred,99,109
tr_B3RT04_OX=10228_GN=TRIADDRAFT_21918_PE=4_SV=1,disordered region,IUPred,121,124
tr_B3RT04_OX=10228_GN=TRIADDRAFT_21918_PE=4_SV=1,disordered region,IUPred,138,142
tr_B3RT04_OX=10228_GN=TRIADDRAFT_21918_PE=4_SV=1,disordered region,IUPred,158,161
tr_B3RT04_OX=10228_GN=TRIADDRAFT_21918_PE=4_SV=1,disordered region,IUPred,249,253
tr_B3RT04_OX=10228_GN=TRIADDRAFT_21918_PE=4_SV=1,disordered region,IUPred,284,290
tr_B3RT04_OX=10228_GN=TRIADDRAFT_21918_PE=4_SV=1,disordered region,BISMMpredictor,5,27
tr_B3RT04_OX=10228_GN=TRIADDRAFT_21918_PE=4_SV=1,disordered region,BISMMpredictor,29,51
tr_B3RT04_OX=10228_GN=TRIADDRAFT_21918_PE=4_SV=1,disordered region,BISMMpredictor,55,73
tr_B3RT04_OX=10228_GN=TRIADDRAFT_21918_PE=4_SV=1,disordered region,BISMMpredictor,107,126
tr_B3RT04_OX=10228_GN=TRIADDRAFT_21918_PE=4_SV=1,disordered region,BISMMpredictor,147,163
tr_B3RT04_OX=10228_GN=TRIADDRAFT_21918_PE=4_SV=1,disordered region,BISMMpredictor,184,200
tr_B3RT04_OX=10228_GN=TRIADDRAFT_21918_PE=4_SV=1,disordered region,BISMMpredictor,253,274
tr_B3RT04_OX=10228_GN=TRIADDRAFT_21918_PE=4_SV=1,disordered region,BISMMpredictor,290,311
tr_B3RT04_OX=10228_GN=TRIADDRAFT_21918_PE=4_SV=1,functional domain,PFAM,83,117,PF02218.16
tr_B3RT04_OX=10228_GN=TRIADDRAFT_21918_PE=4_SV=1,functional domain,PFAM,120,155,PF02218.16
tr_B3RT04_OX=10228_GN=TRIADDRAFT_21918_PE=4_SV=1,functional domain,PFAM,157,192,PF02218.16
tr_B3RT04_OX=10228_GN=TRIADDRAFT_21918_PE=4_SV=1,functional domain,PFAM,194,229,PF02218.16
tr_B3RT04_OX=10228_GN=TRIADDRAFT_21918_PE=4_SV=1,functional domain,PFAM,231,266,PF02218.16
tr_B3RT04_OX=10228_GN=TRIADDRAFT_21918_PE=4_SV=1,functional domain,PFAM,268,303,PF02218.16
tr_B3RT04_OX=10228_GN=TRIADDRAFT_21918_PE=4_SV=1,functional domain,PFAM,305,319,PF02218.16
tr_B3RT04_OX=10228_GN=TRIADDRAFT_21918_PE=4_SV=1,consensus ordered region,TAPASS,91,161
tr_B3RT04_OX=10228_GN=TRIADDRAFT_21918_PE=4_SV=1,consensus ordered region,TAPASS,201,248
tr_B3RT04_OX=10228_GN=TRIADDRAFT_21918_PE=4_SV=1,consensus disordered region,TAPASS,1,90
tr_B3RT04_OX=10228_GN=TRIADDRAFT_21918_PE=4_SV=1,consensus disordered region,TAPASS,162,200
tr_B3RT04_OX=10228_GN=TRIADDRAFT_21918_PE=4_SV=1,consensus disordered region,TAPASS,249,321

Alphafold results - spectrum b

_images/B3RT04alphafold_.png

Alphafold results - units from MRF

_images/B3RT04alphafoldUnits_.png

Alphafold results - spectrum b of the repeat region

_images/B3RT04alphafold.png

AlphaFold results B3RT04

D7EJV2

PFAM repeat regions: 85-120, 657-791, 694-729,731-752

D7EJV2 Interpro sequence information

Sequence:

>tr|D7EJV2|D7EJV2_TRICA Xaa-Pro dipeptidase-like Protein OS=Tribolium castaneum OX=7070 GN=AUGUSTUS-3.0.2_11562 PE=3 SV=1
MWKAAAGQQINLNDQPTEDDEWETDPDFVNDVNEQEQRWGSATIAGSGRTAGAIDMSQLR
KETEEADALKKKKQLEEGASNPAFGYGGKFGIEKDRMDQSAVGHEYVAKVEKHASQKDYS
AGFGGKFGIQADRVDKPYRDDSEQYSLKKIDTKVWDASKPGRLWNGPGTYEIPVELYAEN
RKRLIEQIHAKDPGKPVILLQGGDEIPFYDTDITYSVFRQESNFLWTFGVTEPGCFGAID
IATKKTFLFVPRFPTSYLIWRGPLPSLEDISRKYQIPNVHHKDNIASILRNLNPSVLLTL
KGVNSDSNLLSREAHFEGIDKFRVNNTVLYNEIANLRVYKTDFELDVMRYVSDISSEAHR
KVMRFAKPGKTEYQCEAEFLHYCYATGGCRHTSYTCICASGANGAILHYGHAAAPNNKMI
EPGDLCLFDMGANYFGYCADITCTFPANGKFSPSQKLIYEAVLLTNTTVFKSLKPGVSWL
EMHTLAHRVLLGELKKGGLLKGDVEAMVAAGLGGVFQPHGLGHLLGLDVHDVGGFIGAKR
SDLKGAAMLRTTRELKERMVITVEPGCYFIDVLLDEALESAALSRFLVADVIKRFRGFGG
VRIEDNVLITKNGAVSLTKVPRSVKEVEDWIAGKDSKTWEHKEKIEKHASQKDYVTGFGG
KFGVQTDRQDKSAVGWDHIEKIEKHESQKDYVKGFGGKFGVQSDRQDKSAVGWDHHEAPQ
KHESQTDHKIGFGGKFGLQTDRVDKSAANFNDEPAKVGTNYTKVKPDIGDAKPKDLRAKF
ENMVVFSTIQGAPT

MRF results:

Region 1: 644-754,37 aa length,3 units,T-REKS 0.99
KIEKHASQKDYVTGFGGKFGVQTDRQDKSAVGWDHIE
KIEKHESQKDYVKGFGGKFGVQSDRQDKSAVGWDHHE
APQKHESQTDHKIGFGGKFGLQTDRVDKSAANFNDEP

TAPAS results:

tr_D7EJV2_PE=3_SV=1,structured domain,CATH,169,338,3.40.350.10/FF/6430
tr_D7EJV2_PE=3_SV=1,structured domain,CATH,339,632,3.90.230.10/FF/9102
tr_D7EJV2_PE=3_SV=1,disordered region,IUPred,1,78
tr_D7EJV2_PE=3_SV=1,disordered region,IUPred,86,90
tr_D7EJV2_PE=3_SV=1,disordered region,IUPred,101,108
tr_D7EJV2_PE=3_SV=1,disordered region,IUPred,673,679
tr_D7EJV2_PE=3_SV=1,disordered region,IUPred,704,735
tr_D7EJV2_PE=3_SV=1,disordered region,IUPred,743,774
tr_D7EJV2_PE=3_SV=1,disordered region,BISMMpredictor,11,28
tr_D7EJV2_PE=3_SV=1,disordered region,BISMMpredictor,632,654
tr_D7EJV2_PE=3_SV=1,disordered region,BISMMpredictor,712,731
tr_D7EJV2_PE=3_SV=1,functional domain,PFAM,85,120,PF02218.16
tr_D7EJV2_PE=3_SV=1,functional domain,PFAM,122,136,PF02218.16
tr_D7EJV2_PE=3_SV=1,functional domain,PFAM,177,292,PF05195.17
tr_D7EJV2_PE=3_SV=1,functional domain,PFAM,348,611,PF00557.25
tr_D7EJV2_PE=3_SV=1,functional domain,PFAM,637,654,PF02218.16
tr_D7EJV2_PE=3_SV=1,functional domain,PFAM,657,691,PF02218.16
tr_D7EJV2_PE=3_SV=1,functional domain,PFAM,694,728,PF02218.16
tr_D7EJV2_PE=3_SV=1,functional domain,PFAM,731,752,PF02218.16
tr_D7EJV2_PE=3_SV=1,consensus ordered region,TAPASS,109,632
tr_D7EJV2_PE=3_SV=1,consensus disordered region,TAPASS,1,108
tr_D7EJV2_PE=3_SV=1,consensus disordered region,TAPASS,633,794
_images/D7EJV2tapass.jpg

Alphafold results - spectrum b

_images/D7EJV2alphafold.png

Alphafold results - units from MRF

_images/D7EJV2alphafoldUnits.png

Alpha fold results D7EJV2

A0A6G0T661

PFAM repe

A0A6G0T661 Interpro sequence information

Sequence:

>tr|A0A6G0T661|A0A6G0T661_APHGL SH3 domain-containing protein OS=Aphis glycines OX=307491 GN=AGLY_013268 PE=4 SV=1
MWKSAAGVNVEIPVENTDDDWETDPDFVNDVSEEEQRWGSRTVPGSGRVLDHVDMSQLRE
EVTKAHEVQKKKEMEEGPQAAFGYGGKFGVQSDRMDKSAVGHDYIAPHFKHASQTDYSSG
FGGKYGVQSDRIDKSAVSWSHKEKVEKHGSQKDYSSGFGGKFGVQADRQDKSAVGWDYVE
KLQKHESQKDYAVGFGGKFGVQSDRQDKSAVGWDNVETVEKHQSQVDHSKGFGGKFGVQN
DRIDKSAHNYNESSGQVGTNYEKQKPEITSIKPSSLRAKFENMAKQEEEENEKRRLVEQE
RRKQRELQEKKEAREREEKRLKELQEKEEQKQKLLDGSEQIKNTPITKIDYDEEESPISN
EFIRPPVVVGATIQPSVKNDEEALKRIVADEEDRKRKEQAKLEKENTMLKQKQKEEEKIN
EELLKENEKKKLEDLARAELKKKAEEEKIIEDKKILEATRKKLEEEAIQKKLEEESIKKK
LEEESIKKKLEEESIKKKLEEELIKKKLDEETTKLKLEEEAKKKEEQNRLEEERQLEEQK
LHEQLKNGATSEEDPEGGYMAVALYDYQASADDEISFDPDDIVTNIEMIDKGWWRGLCKG
QYGLFPANYVEIIE

MRF results:

Region 1: 84-231, 41 aa length,4 units,T-REKS 0.98
YGGKFGVQSDRMDKSAVGHDYIAPHFKHASQTDYSSGFGGK
----YGVQSDRIDKSAVSWSHKEKVEKHGSQKDYSSGFGGK
----FGVQADRQDKSAVGWDYVEKLQKHESQKDYAVGFGGK
----FGVQSDRQDKSAVGWDNVETVEKHQSQVDHSKG----

Region 2: 460-513, 9 aa length,6 units,TRUST 1.0
RKKLEEEAI
QKKLEEESI
KKKLEEESI
KKKLEEESI
KKKLEEELI
KKKLDEETT

TAPAS results:

tr_A0A6G0T661_PE=4_SV=1,structured domain,CATH,543,614,2.30.30.40/FF/19446
tr_A0A6G0T661_PE=4_SV=1,disordered region,IUPred,6,88
tr_A0A6G0T661_PE=4_SV=1,disordered region,IUPred,99,105
tr_A0A6G0T661_PE=4_SV=1,disordered region,IUPred,136,162
tr_A0A6G0T661_PE=4_SV=1,disordered region,IUPred,175,179
tr_A0A6G0T661_PE=4_SV=1,disordered region,IUPred,193,198
tr_A0A6G0T661_PE=4_SV=1,disordered region,IUPred,209,425
tr_A0A6G0T661_PE=4_SV=1,disordered region,IUPred,515,563
tr_A0A6G0T661_PE=4_SV=1,disordered region,BISMMpredictor,29,49
tr_A0A6G0T661_PE=4_SV=1,disordered region,BISMMpredictor,110,126
tr_A0A6G0T661_PE=4_SV=1,disordered region,BISMMpredictor,138,163
tr_A0A6G0T661_PE=4_SV=1,disordered region,BISMMpredictor,217,237
tr_A0A6G0T661_PE=4_SV=1,disordered region,BISMMpredictor,248,270
tr_A0A6G0T661_PE=4_SV=1,disordered region,BISMMpredictor,297,323
tr_A0A6G0T661_PE=4_SV=1,disordered region,BISMMpredictor,468,503
tr_A0A6G0T661_PE=4_SV=1,disordered region,BISMMpredictor,516,559
tr_A0A6G0T661_PE=4_SV=1,functional domain,PFAM,83,118,PF02218.16
tr_A0A6G0T661_PE=4_SV=1,functional domain,PFAM,120,155,PF02218.16
tr_A0A6G0T661_PE=4_SV=1,functional domain,PFAM,157,192,PF02218.16
tr_A0A6G0T661_PE=4_SV=1,functional domain,PFAM,194,229,PF02218.16
tr_A0A6G0T661_PE=4_SV=1,functional domain,PFAM,231,253,PF02218.16
tr_A0A6G0T661_PE=4_SV=1,functional domain,PFAM,563,611,PF14604.7
tr_A0A6G0T661_PE=4_SV=1,consensus ordered region,TAPASS,426,467
tr_A0A6G0T661_PE=4_SV=1,consensus ordered region,TAPASS,543,613
tr_A0A6G0T661_PE=4_SV=1,consensus disordered region,TAPASS,1,425
tr_A0A6G0T661_PE=4_SV=1,consensus disordered region,TAPASS,468,542

Alphafold results - spectrum b

_images/A0A6G0T661alphafold.png

Alphafold results - units from MRF

_images/A0A6G0T661alphafoldUnits.png

Alpha fold results A0A6G0T661

A0A6Q2YKY6

A0A6Q2YKY6 Interpro sequence information

Sequence:

>tr|A0A6Q2YKY6|A0A6Q2YKY6_ESOLU Cortactin OS=Esox lucius OX=8010 PE=4 SV=1
MWKAAAGQSVTVPLDAGGDDWETDPDFENDVSEKEQRWGAKTVEGSGHQEHINIHKLREN
VSSEHSDLRQKELANMPKASDGYGGKFGVQQDRMDKSAVGWDHQEKLQLHESQKVNVFPA
DALTDEYGEDLGQTAVALYDYQAAGDDEISFDPDDIITNIEMIDEGWWRGVCRGAYGLFP
ANYVELRQ

MRF results:

Region 1: 27-137,43 aa length,3 units,TRUST 0.52

FE-N----DVSEKEQRWG-AKTVEGSGHQEHINIHKL-RENVS
SEHS----DLRQKELANM-PKASDGYGGKFGVQQDRMDKSAVG
WD-HQEKLQLHESQKVNVFP--ADALTDEYG--ED-LGQTAVA

TAPAS results:

tr_A0A6Q2YKY6_SV=1,structured domain,CATH,114,188,2.30.30.40/FF/19446
tr_A0A6Q2YKY6_SV=1,disordered region,IUPred,1,87
tr_A0A6Q2YKY6_SV=1,disordered region,IUPred,98,105
tr_A0A6Q2YKY6_SV=1,disordered region,BISMMpredictor,15,39
tr_A0A6Q2YKY6_SV=1,disordered region,BISMMpredictor,55,73
tr_A0A6Q2YKY6_SV=1,functional domain,PFAM,82,114,PF02218.16
tr_A0A6Q2YKY6_SV=1,functional domain,PFAM,137,185,PF14604.7
tr_A0A6Q2YKY6_SV=1,consensus ordered region,TAPASS,106,188
tr_A0A6Q2YKY6_SV=1,consensus disordered region,TAPASS,1,105
_images/A0A6Q2YKY6tapass.jpg

Alphafold results - spectrum b

_images/A0A6Q2YKY6alphafold.png

Alphafold results - units from MRF

_images/A0A6Q2YKY6alphafoldUnits.png

Alpha fold results A0A6Q2YKY6